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Williams Textbook of Endocrinology 14th Edition

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Expertly bridging the gap between basic science and clinical information, Williams Textbook of Endocrinology, 14th Edition, brings together an outstanding collection of world-renowned authors to provide authoritative discussions of the full spectrum of adult and pediatric endocrine system disorders. New chapters and significant revisions throughout keep you up to date with recent advances in medications, therapies, clinical trials, and more. This essential reference is a must-have resource for endocrinologists, endocrine surgeons, gynecologists, internists, pediatricians, and other clinicians who need current, comprehensive coverage of this multifaceted field.
Up to date with recent advances in medications, therapies, and clinical trials.

Provides state-of-the-art coverage of diabetes, metabolic syndrome, metabolic bones disorders, obesity, thyroid disease, testicular disorders, newly defined adrenal disorders and much more – all designed to help you provide optimal care to every patient.

Contains new chapters on Global Burden of Endocrine Disease, Navigation of Endocrine Guidelines, and Transgender Endocrinology.

Includes significant updates to the Diabetes section, including a new chapter on Physiology of Insulin Secretion and greater coverage of Type 2 Diabetes.

Presents current information in a highly illustrated, user-friendly format for quick reference. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Williams Textbook of Endocrinology
1 – Principles of Endocrinology
The Evolutionary Perspective
Endocrine Glands
Transport of Hormones in Blood
Target Cells as Active Participants
Control of Hormone Secretion
Hormone Measurement
Endocrine Diseases
Hormone Overproduction
Hormone Underproduction
Altered Tissue Responses to Hormones
Tumors of Endocrine Glands
Excessive Hormone Inactivation or Destruction
Diagnostic and Therapeutic Uses of Hormones
Future Perspectives
2 – Principles of Hormone Action
Introduction to Hormone Signaling
Ligands That Act Through Cell Surface Receptors
Classic Peptide Hormones
Nonpeptide Hormones That Act at Cell Surface Receptors
Binding Properties of Cell Surface Receptors
Cell Surface Hormone Receptors
Ligand-Gated Ion Channels
G Protein–Coupled Receptors
Signaling by Heterotrimeric G Proteins
Receptor Tyrosine Protein Kinases as Cell Surface Receptors
Signaling by Receptor Tyrosine Protein Kinases
Receptor Serine/Threonine Protein Kinases
Signaling by Receptors That Associate With Enzymes
Coupling of Cell Surface Receptors to Intracellular Signaling
Downstream Signaling by Cyclic Adenosine Monophosphate
Regulation by the Second Messengers Calcium and PKC
Regulation of Protein Kinases by PI3K
Regulation of Protein Kinases by Ras
Disease Caused by Defective Cell Surface Receptors
Insulin Resistance Syndromes
Defects in Cell Surface Receptors That Control Growth
Diseases Caused by Mutations in GPCRs and G Proteins
Ligands That Act Through Nuclear Receptors
General Features of Nuclear Receptor Ligands
Subclasses of Nuclear Receptor Ligands
Classic Hormones
Metabolic Intermediates and Products
Endobiotics and Xenobiotics
Orphan Receptors
Variant Receptors
Regulation of Ligand Levels
Nuclear Receptor Signaling Mechanisms
Domain Structure of Nuclear Receptors
Nuclear Localization
Hormone Binding
Target Gene Recognition by Receptors
Receptor Dimerization
Receptor Regulation of Gene Transcription
Ligand-Dependent Activation
Repression of Gene Expression by Unliganded Receptor
Ligand-Dependent Negative Regulation of Gene Expression: Transrepression
Roles of Other Nuclear Receptor Domains
Cross-Talk With Other Signaling Pathways
Receptor Antagonists
Tissue Selectivity of Ligands Interacting With Nuclear Receptors
Nongenomic Actions of Nuclear Receptor Ligands
3 – Genetics of Endocrinology
The Role of Genetics in Endocrinology
Principles of Genetics
A Brief Historical Perspectiv



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